New Constructions of Zero-Correlation Zone Sequences

In this paper, we propose three classes of systematic approaches for constructing zero correlation zone (ZCZ) sequence families. In most cases, these approaches are capable of generating sequence families that achieve the upper bounds on the family size ($K$) and the ZCZ width ($T$) for a given sequence period ($N$). Our approaches can produce various binary and polyphase ZCZ families with desired parameters $(N,K,T)$ and alphabet size. They also provide additional tradeoffs amongst the above four system parameters and are less constrained by the alphabet size. Furthermore, the constructed families have nested-like property that can be either decomposed or combined to constitute smaller or larger ZCZ sequence sets. We make detailed comparisons with related works and present some extended properties. For each approach, we provide examples to numerically illustrate the proposed construction procedure.Comment: 37 pages, submitted to IEEE Transactions on Information Theor

Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia

<p>Abstracts</p> <p>Recent studies have demonstrated the importance of anti-inflammation, including cellular immunity, inflammatory mediators, reactive oxygen species, nitric oxide and several transcriptional factors, in the treatment of cerebral ischemia. This article reviews the roles of Chinese medicinal herbs as well as their ingredients in the inflammatory cascade induced by cerebral ischemia. Chinese medicinal herbs exert neuroprotective effects on cerebral ischemia. The effects include inhibiting the activation of microglia, decreasing levels of adhesion molecules such as intracellular adhesion molecule-1, attenuating expression of pro-inflammatory cytokines such as interleukin-1β and tumor necrosis factor-α, reducing inducible nitric oxide synthase and reactive oxygen species, and regulating transcription factors such as nuclear factor-κB.</p

Utilized mass spectrometry-based protein profiling system to identify potential biomarkers of hepatocellular carcinoma

AbstractHepatocellular carcinoma (HCC) is the most common malignant liver tumor. The purpose of this study is to characterize proteins secreted from the HepG2 cells, which may relate to cell differentiation and tumor metastasis. In the proteomic analysis, the secretome was identified by nano-high–performance liquid chromatography/electrospray ionization tandem mass spectrometry (nano-HPLC/ESIMS/MS) followed by peptide fragmentation pattern analysis. In this study, three proteins, p130Cas-associated protein (p130Cas/BCAR1), TAR DNA-binding protein 43 (TDP43/TARDBP) and translationally controlled tumor protein (TCTP/TPT1), were identified and confirmed by Western blotting, which showed significantly differential expression compared with the normal liver cells. Analyzing differential protein expressions in HepG2 cell by proteomic approaches suggests that p130Cas/BCAR1, TDP43/TARDBP and TCTP/TPT1 as key proteins and may serve as biomarkers for HCC

Effect of the Kinesio tape to muscle activity and vertical jump performance in healthy inactive people

BACKGROUND: Elastic taping applied on the triceps surae has been commonly used to improve the performance of lower extremities. However, little objective evidence has been documented. The purpose of this study was to investigate the effect of elastic taping on the triceps surae during a maximal vertical jump. It was hypothesized that elastic taping to the triceps surae would increase muscle activity and cause positive effect to jump height. METHODS: Thirty-one healthy adults (19 males and 12 females with mean age, body weight and height for 25.3 ± 3.8 years old, 64.1 ± 6.2 kg, and 169.4 ± 7.3 cm, respectively) were recruited. All participants performed vertical jump tests prior to (without taping) and during elastic taping. Two elastic tapes, Kinesio tape and Mplacebo tape from two different manufacturers, were applied to the participants, respectively. RESULTS: The results showed that the vertical ground reaction force increased when Kinesio tape was applied even when the height of jump remained about constant. However, the height of the jump decreased, and there was no difference on the vertical ground reaction force in Mplacebo taping group. Although the EMG activity of medial gastrocnemius tended to increase in Kinesio taping group, we did not see differences in EMG activity for the medial gastrocnemius, tibialis anterior and soleus muscles in either group. CONCLUSIONS: Based on the varied effects of Kinesio tape and Mplacebo tape, different intervention technique was suggested for specific purpose during vertical jump movement. Mplacebo tape was demanded for the benefits of stabilization, protection, and the restriction of motion at the ankle joint. On the other hand, the findings may implicate benefits for medial gastrocnemius muscle strength and push-off force when using Kinesio tape

Paeonol Protects Memory after Ischemic Stroke via Inhibiting β-Secretase and Apoptosis

Poststroke dementia commonly occurs following stroke, with its pathogenesis related to β-amyloid production and apoptosis. The present study evaluate the effects of paeonol, one of the phenolic phytochemicals isolated from the Chinese herb Paeonia suffruticosa Andrews (MC), on protection from memory loss after ischemic stroke in the subacute stage. Rats were subjected to transient middle cerebral artery occlusion (tMCAo) with 10 min of ischemia. The data revealed that paeonol recovered the step-through latency in the retrieval test seven days after tMCAo, but did not improve the neurological deficit induced by tMCAo. Levels of Amyloid precursor protein (APP)- and beta-site APP cleaving enzyme (BACE; β-secretase)-immunoreactive cells, and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells decreased in the paeonol-administered group. Western blotting revealed decreased levels of Bax protein in mitochondria and apoptosis-inducing factor (AIF) in cytosol following paeonol treatment. In conclusion, we speculate that paeonol protected memory after ischemic stroke via reducing APP, BACE, and apoptosis. Supression the level of Bax and blocking the release of AIF into cytosol might participate in the anti-apoptosis provided by paeonol

Local Periodicity-Based Beat Tracking for Expressive Classical Piano Music

To model the periodicity of beats, state-of-the-art beat tracking systems use "post-processing trackers" (PPTs) that rely on several empirically determined global assumptions for tempo transition, which work well for music with a steady tempo. For expressive classical music, however, these assumptions can be too rigid. With two large datasets of Western classical piano music, namely the Aligned Scores and Performances (ASAP) dataset and a dataset of Chopin's Mazurkas (Maz-5), we report on experiments showing the failure of existing PPTs to cope with local tempo changes, thus calling for new methods. In this paper, we propose a new local periodicity-based PPT, called predominant local pulse-based dynamic programming (PLPDP) tracking, that allows for more flexible tempo transitions. Specifically, the new PPT incorporates a method called "predominant local pulses" (PLP) in combination with a dynamic programming (DP) component to jointly consider the locally detected periodicity and beat activation strength at each time instant. Accordingly, PLPDP accounts for the local periodicity, rather than relying on a global tempo assumption. Compared to existing PPTs, PLPDP particularly enhances the recall values at the cost of a lower precision, resulting in an overall improvement of F1-score for beat tracking in ASAP (from 0.473 to 0.493) and Maz-5 (from 0.595 to 0.838).Comment: Accepted to IEEE/ACM Transactions on Audio, Speech, and Language Processing (July 2023